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The authors of the meta-analysis examined if maternal serum homocysteine levels, folic acid supplementation, or gestational age could explain the variation in the results, but none significantly explained the difference between studies

Some more stable peptides can last 4-6 weeks, while fragile ones may show significant degradation by week 2

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Be concerned if spasms occur multiple times per week, are severe or long-lasting, affect multiple body areas, are accompanied by muscle weakness, numbness, or tingling