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In early work, a hairpin pyrrole-imidazole polyamide was designed to target the ARE to disrupt AR DBD binding and was effective at inhibiting androgen-induced PSA expression in LNCaP cells 181

The following adverse reactions have been reported: Neurologic Reactions: Seizures have been reported to occur in patients, with or without pre-existing seizure activity, receiving either oral or intravenous levocarnitine

Calcium oxalate (CaOx) crystal treatment obviously elevated the cellular iron concentration, enhanced lipid peroxidation, and reduced the expression of GPX4 and SCL7A11 in vivo and in vitro