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GLP-1 Receptor Activation The GLP-1 receptor component provides effects that have become the cornerstone of modern obesity pharmacotherapy: activation of GLP-1 receptors in the hypothalamus and brainstem powerfully suppresses appetite and induces satiety through effects on proopiomelanocortin (POMC) neurons and other appetite-regulatory circuits, leading to substantial reductions in caloric intake

Studies on GLP-1 drugs, specifically Semaglutide and Tirzepatide, reveal a clear trend: patients who stop these medications abruptly tend to regain most of the lost weight

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The amylin-based mechanism may contribute to this selectivity