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Additionally, ROS activate the hypoxia-inducible factor-1 alpha (HIF-1) pathway, leading to increased expression of vascular endothelial growth factor (VEGF) and the formation of retinal neovascularization [186]

PLoS ONE 12:e0184098

Abdellatif, M

The relatively large VIP values of -GluCys (2.26), LA (1.98), and D-lactate (1.70) showed that these metabolites were the main contributors to the patient-group separation in this study