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Muchas personas experimentan efectos secundarios, particularmente nuseas y diarrea

Semaglutide and Metabolic Inflammation: A Cortisol Connection Chronic elevation of cortisol drives systemic inflammation, which in turn perpetuates obesity, insulin resistance, and metabolic syndrome

This can enhance the blood sugar-lowering effects of semaglutide and improve overall glycemic control

However, this gives a signal of a favorable effect of GLP-1 receptor agonist therapy in the COPD population, as was also previously shown in a similar study in the UK, where a 30% reduction per 100 person years of severe exacerbations was recorded in GLP-1 receptor agonist users compared to sulfonylurea users, as well as a 37% reduction per 100 person years of moderate exacerbations