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Mechanistically, Gln deprivation increases slug expression by triggering the ATF4 and MEK/ERK signaling pathways, thereby inducing EMT and promoting the metastasis of PDAC cells

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[40] reported that InsR specifically phosphorylated STAT3 factor and stimulated its transactivating capacity in a manner which was independent of p21Ras and MAPK signaling, i.e., the other pathways activated by InsR/IGF-1R signaling