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During their conversion to R2 reticulocytes, which are consequently released into the bloodstream, R1 reticulocytes lose excess plasma membrane

This combination also exhibited excellent bacterial-killing effect, wound-healing, and low biotoxicity in a S

Randomization controls for known and unknown confounders that could influence the treatment outcome and a control (placebo, untreated, or standard care) group allows for the estimation of the average effect of treatment in treated relative to untreated patients