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Myeloid compartment Monocytes/Macrophages and ASCVD Classical monocyte-derived macrophages are important in the early steps of atherogenesis as they contribute significantly to the creation of an inflammatory microenvironment

This survival mechanism leads to inappropriate tachycardia (rapid heart rate), severe palpitations, blood pressure fluctuations, and profound orthostatic intolerance when standing

Currently approved approaches operate in three directions: 1) providing exogenous NO, 2) promoting sGC activity, and 3) preventing degradation of cGMP by inhibiting phosphodiesterase 5 activity

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