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In a double-blind, placebo-controlled trial in 11 smokers and 13 nonsmokers given -tocopherol and -tocopherol that was labeled with deuterium, supplementation with vitamin C reduced the rate of vitamin E loss in plasma, likely by regenerating tocopheryl radicals back to nonoxidized forms (22)

Importantly, crucial fatigue, exercise intolerance and myalgia are not specific of ME/CFS, but are shared by patients suffering from primary mitochondrial diseases with mutations in either nuclear or mitochondrial DNA (188)

10.1038/cdd.2011.96 51 GaoM.MonianP.QuadriN.RamasamyR.JiangX