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doi: 10.1073/PNAS.092672899 52 Garca-SezAJ

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In this article, we have presented a conceptualization of neurodegenerative disorders as metabolic icebergs, which conveys the hallmark clinical, anatomical, and pathological features (tip) as late-stage effects of impaired mitochondrial biology (bulk), which in turn is induced by a suite of environmental and genetic factors (base)