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Benn CL, Dua P, Gurrell R, Loudon P, Pike A, Storer RI, et al

Regulation of Calcitonin Secretion in Normal Man by Changes of Serum Calcium within the Physiologic Range

The mechanism is purely metabolic: increased energy expenditure , suppressed lipogenesis, and elevated NAD+ levels that activate sirtuins (SIRT1, SIRT3), the same longevity-associated enzymes targeted by caloric restriction

Patients with certain GLP1R polymorphisms, for example, may achieve faster satiety if they inject consistently at the same hour each week, while others show equal benefit across variable timing