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Upregulation of sense gene via NAT degradation While the previously mentioned mechanisms function to upregulate the sense gene by directly acting upon the sense gene mRNA transcript, one limitation lies in the fact that uORFs only exist in approximately 50% of mammalian mRNA and within this 50%, not all are inhibitory [106, 107]

Patients with specific variants may benefit from morning injection to catch early response, while others with FTO variants linked to evening hunger surges may prefer evening dosing

10.1093/jnen/nlab018 156 PillaiR.LeBoeufS