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The pathway analysis by KEGG on differentially expressed proteins suggested that the significantly affected pathways were steroid hormone biosynthesis, propanoate metabolism, systemic lupus erythematosus, non-alcoholic fatty liver disease (NAFLD), fatty acid degradation, fatty acid metabolism, citrate cycle (TCA cycle), carbon metabolism, fat digestion and absorption, Parkinsons disease (PD), oxidative phosphorylation, ubiquinone and other terpenoid-quinone biosynthesis, alcoholism (Fig

Exercise Mimetic and Cellular Adaptation Effects MOTS-c levels increase following physical activity, indicating responsiveness to metabolic demand

126 In liver fibrosis models, SIRT1 activation reduces Th2-derived pro-fibrotic cytokine levels