IGF-1 Upregulation Downstream Anabolic Signaling Both peptides indirectly stimulate insulin-like growth factor-1 (IGF-1) production through sustained growth hormone elevation: Growth hormone binds to hepatic GH receptors activating JAK-STAT signaling pathways Increased transcription of IGF-1 gene in liver tissue Elevated plasma IGF-1 levels mediate anabolic effects in muscle, bone, and adipose tissue IGF-1 provides negative feedback regulation preventing excessive growth hormone secretion Studies report IGF-1 increases of 1.5- to 3-fold for 9-11 days following CJC-1295 administration, with the ipamorelin combination providing more sustained elevation
It isnt clear how the synergy arises, but additional research using the peptide may reveal novel pathways for improving cartilage growth, a notoriously challenging clinical problem
A 30 mg tirzepatide vial with 3 mL of bacteriostatic water makes 10 mg/mL, where 5 mg draws 50 units and 10 mg draws 100 units
Retrieved November 9, 2021 from Urbanski, G., Hamel, J.-F., Prouveur, B., Annweiler, C., Ghali, A., Cassereau, J., et al
