The rate shows a clear dose-response pattern: in the SURMOUNT-1 trial published in the New England Journal of Medicine (N=2,539 adults followed for 72 weeks), reported rates climbed from roughly 12% at the 2.5 mg starting dose to 23% at the 15 mg top dose, compared to about 8% on placebo
[1] Some people with autism (~10-20%) seem to have L-carnitine metabolism disorders and for these patients, a diet high in carnitine and dietary supplementation with L-carnitine is beneficial
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Quantification of lipogenesis gene expression To quantify gene expression, we used the Pure Link RNA Mini kit (12183025, Invitrogen, USA), Hilden, Germany) to extract total RNA from untreated and treated HepG2 cells and used High-Capacity cDNA Reverse Transcription kit (4368813, Applied Biosystems, Foster City, CA, USA) and 2 g total RNA to prepare cDNA
