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There is no single ceiling for sugar reduction, but there are clear technical limits that vary by category, Lotay says

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[31] Proportions of side effects were not noted in the phase 2 study, but results from an earlier phase 1 study, with 8 obese patients receiving weekly Mazdutide (9 mg) showed side effects of nausea (62.5% of patients), diarrhea (25%) and vomiting (37.5%) were seen after 12 weeks [32] , although it must be noted that these numbers probably deviate largely from the results in the phase 2 study, simply due to sheer differences in sample sizes

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