FDA News Release: FDA approves Otezla to treat psoriatic arthritis
Setmelanotide is a disulfide cyclic synthetic peptide, eight amino acids long, capable of crossing the blood-brain barrier 37 where at its site of action in the hypothalamus, it can activate several melanocortin receptors 37
The cytoprotection concept holds innate cell (epithelial (Robert) [41,42,43], endothelial (Szabo) [44,45,46,47]) integrity, even against opposite damaging necrotizing agents (i.e., strong alcohol, boiling water, strong acid, strong base [41]) and protection/maintenance/reestablishment in the stomach to be translated to other organ therapy (cytoprotection organoprotection) [48,49] via the cytoprotection agents effect
Richie, J.P