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LPO products hinder the activation and signalling of AKT via the down-regulation of phosphorylation of important sites

It combines well with KPV and thymosin alpha-1, with LL-37 addressing microbial triggers while the other peptides handle immune regulation

To reduce the risk of misdiagnosis and overtreatment, the clinical expert consulted by CADTH suggested that treatment decisions be made by a panel of clinical experts, at least when the diagnosis of SPIGFD is uncertain

However, no differences in serum glutathione reductase (an antioxidant enzyme involved in GSH synthesis) and in the total antioxidant status were found, likely suggesting rapid exhaustion of the antioxidant system (10)