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There have been postmarketing reports of renal impairment, acute kidney injury, and worsening of chronic renal failure, which sometimes has required hemodialysis, in patients treated with GLP-1 receptor agonists

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In another study, systems pharmacology modeling predicted multi-target interactions of resveratrol in AD, highlighting its regulatory effects on autophagy-related genes and its involvement in the PI3K/Akt/mTOR signaling axis (Li Y