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This makes it a useful tool for researchers studying: Regulation of adipose tissue metabolism Energy balance and obesity-related pathways Joint and cartilage biology in osteoarthritis models Metabolic factors associated with cardiovascular and systemic syndromes In animal studies, AOD9604 has been reported to stimulate lipolysis and inhibit lipogenesis under specific experimental conditions, providing a platform to dissect signaling mechanisms involved in fat turnover and metabolic control

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metabolite Ac-LKKTE identified as potentially more active than parent compound Paradoxical finding: Both peptides show biological effects persisting hours to days after administration despite rapid plasma clearance Possible explanations: Tissue retention, active metabolites, or persistent signaling cascade activation Excretion Pathways Limited data exists on excretion for both peptides[22]: Likely renal elimination of peptide fragments Hepatic metabolism may contribute to clearance No accumulation detected in chronic dosing studies (animal models) Combined excretion kinetics have not been characterized in any species The disconnect between short plasma half-lives and prolonged biological effects represents a key area requiring mechanistic clarification for both individual peptides and their combination