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Evolution and challenges of new obesity drugs related to adverse effects and future direction Combatting obesity represents a major health dilemma, as it contributes to a heightened risk of disease, diminishes the quality of life, and can reduce life expectancy

Diagnosed with MASH (not just fatty liver/NAFLDmust be steatohepatitis) Moderate to advanced fibrosis (stages F2-F3, confirmed by FibroScan or biopsy) No cirrhosis (the approval is for noncirrhotic MASH only) Why This Matters for Coverage Bypass weight loss exclusions: Plans that exclude obesity drugs may cover liver disease treatments Medicare Part D potential: Like the CV indication, MASH may provide a pathway around the weight loss drug exclusion Different PA criteria: Liver disease documentation (FibroScan, biopsy, liver enzymes) may be easier to obtain than weight loss program history Do You Have MASH

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The 16 kDa prolactin isoform is a cleavage product derived from native prolactin, which has received particular attention as a result of its newly described inhibitory effects on angiogenesis and tumorigenesis