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In animal studies, particularly in rats, kavainthe primary kavalactone found in traditional kava preparationswas shown to be well absorbed, with an estimated bioavailability of approximately 50%

As referred, the decomposition of H 2 O 2 is particularly important in erythrocytes, to prevent oxidation of Hb and of other RBC constituents

With breach of the blood-brain barrier, immune cells infiltration as well as extravasation of blood-borne molecules such as fibronectin triggers, together with the death of oligodendrocytes, degeneration and transection of axons and starts a multicellular inflammatory response associated with reactive astro- and microgliosis