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The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages

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Researchers have found that PINK1/Parkin-mediated mitophagy is activated in db/db mice, after treatment with Huangqi-Danshen decoction (HDD), enhanced mitochondrial fission and PINK1/Parkin-mediated mitophagy were inhibited in db/db mice, improving kidney damage in db/db mice [152]