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Hydration benefits are often immediate, while vitamin and antioxidant effects tend to build with regular sessions

doi:10.1021/tx980224j Srinivas KSV, Buchireddy R, Madhusudhan G et al (2008) Stress degradation studies on aripiprazole and development of a validated stability indicating LC method

Unlike fat-soluble vitamins (A, D, E, and K) that can build up, B12 has a strong safety record and toxicity is rare

[DOI] [PMC free article] [PubMed] [Google Scholar] 238.de Visser KE, Jonkers J