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High content analysis (HCA) of acquired images was performed using the IN Cell Investigator 2.7.3 software (GE Healthcare) or IN Carta v1.17.0412545 software (Molecular Devices)

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[93] Patients experiencing persistent or severe headaches should be evaluated for other potential causes, and dose reduction or treatment discontinuation may be necessary

* Correspondence: Yuzhen Wang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers