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This reverse transport actively pumps the newly accumulated cytosolic monoamines out of the neuron and into the synaptic cleft (Martin & Le, 2023)

Many of those studies demonstrated an acute beneficial effect, however, liver toxicity associate with frequent use of CGRP small molecule inhibitors has hampered progress

doi: 10.1002/art.39117 114 LiNWeiWYinFChenMMaTRWuQet al

Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids