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Additionally, the combined expression of IL-17A, IL-17F, IL-21, retinoic acid receptor-related orphan receptor C (RORC), and transforming growth factor (TGF)- mRNA significantly predicted the rachmilewitz endoscopic index (REI), with IL-17A and IL-17F being associated with increased and decreased REI, respectively [67]

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Overall, plasma citrulline is a functional (albeit unvalidated) marker of gut barrier dysfunction (Dey and Bhattacharjee, 2020), and lack of it has been associated with various intestinal diseases, including short bowel syndrome (Jeppesen et al., 2020

The P72R SNP has previously been described as differentially impacting somatically mutated p53 proteins on a functional and potentially structural level [15,16,17,18]