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In other words, the NRF2 factor controls gene expression and the regulation of antioxidant and detoxifying enzymes [150] since it modulates the expression of more than 200 genes found in the promoter region of the antioxidant response (ARE) [151]

Preclinical research suggests it interacts with GABAergic and HPA-axis-linked signaling, making it a central tool for investigations related to sleep disorders, stress management, and neuropeptide modulation under defined experimental conditions

Archived from the original on December 2, 2016