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Sixty-nine patients (25% of those enrolled) were affected by a mecasermin shortage over the course of the study, resulting in a dosage decrease or dose interruption

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While glutathione is generally considered safe when used appropriately, some individuals may experience side effects, especially with high-dose injections

181 Similarly, sclareol significantly decreased levels of IL-1, TNF-, and IL-6 in Crohns disease models while upregulating tight junction proteins and preserving mucosal structure, indicating immunomodulatory and barrier-stabilizing roles