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Tingling or Numbness (Paresthesia): Changes in GH and IGF-1 can occasionally lead to a sensation of tingling, often in the hands or feet

Activation involves signaling pathways such as JAKSTAT, NF-B, mitogen-activated protein kinase (MAPK) and calcineurin, leading to cytoskeletal changes marked by the upregulation of GFAP, vimentin and nestin 35,44,45

British Journal of Biomedical Science, 70, 759

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