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To improve transparency, an adapted PRISMA-style flow diagram documenting identification, screening, eligibility assessment, de-duplication, and selection of the RCT evidence base and the proof-of-concept Bayesian subset is provided in the Supplementary Appendix Figure 1, together with details of the search strategy, screening process, and data extraction

Targeting A 2A R with classic pharmacology has shown some drawbacks, including slow and imprecise drug delivery and low specificity and efficacy [21]

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