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Theoretically, that could mean it would affect the levels of the medication in the bloodstream, potentially affecting the medications effectiveness when it comes to preventing pregnancy

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The review would benefit from a bit more text on how this notion impacts the balance between desired therapeutic effects, "diluted" effects from dimer-mediated versus non-dimer effects, and undesired off-target effects (which are discussed some in terms of receptor specificity, but not in terms of anatomy, where the same dimer may have different effects in different brain regions). Response: We have added a new section title General treatment approaches before the concluding remarks

IGF-1LR3 has a more potent effect than the natural IGF-1 hormone because it prolongs the molecule and has a longer-lasting effect in the body