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Efficacy and safety of the glucagon receptor antagonist volagidemab in type-1 diabetes: A systematic review and meta-analysis

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The study design followed the validated Wistar-Kyoto + chronic mild stress (WKY/CMS) framework, a translational model of treatment-resistant depression (TRD) that combines genetic vulnerability and environmental stress exposure

Without a head-to-head trial, definitive superiority cannot be established