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Ganetespib acts as a radiosensitizer in pancreatic ductal adenocarcinoma by disrupting HIF-1, STAT3, and AKT signaling and inducing G2-M cell cycle arrest, thereby impairing DNA damage repair during irradiation

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Peroxiredoxins (Prdx) Peroxiredoxins (Prdxs) are cysteine-dependent peroxidase enzymes [132,175], whose low Km for H 2 O 2 (10 M) and their ubiquity, comprising up to 0.8% of total protein in some animal cells predispose them for reduction H 2 O 2 [176]

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