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Accordingly, male PAR2-G37I mice showed improved glucose tolerance in a GTT, whereas male PAR2-R38E mice showed a partial, insignificant reduction in glucose levels (Figure 3, D and F)
However, another analysis based on data from three European countries did not confirm this signal, suggesting that the increased risk associated with GLP-1RAs may not be significant compared to SGLT-2 inhibitors among T2DM patients [16]
Nearly 2 in 3 people in the study who took a 12 milligram dose over 80 weeks lost enough weight to fall below the obesity measure based on a person's height and weight
PMID 14499707
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