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Several are already available in retail pharmacies at prices 60 per cent to 90 per cent lower than those of international brands, prompting Novo Nordisk to cut prices of Ozempic and Wegovy in India by 36 per cent to 48 per cent this week

My general framework: Start with semaglutide if cost is a significant concern, or if there is no strong reason to expect poor tolerance Start with tirzepatide if the patient has tried semaglutide before and struggled with side effects, if faster initial response matters clinically, or if the patients goals require larger total weight loss Switch to tirzepatide if a patient on semaglutide is experiencing persistent nausea or has plateaued and escalation options are limited One pattern worth noting: men I see a consistent pattern with male patients who struggle to tolerate semaglutide nausea and GI disruption can be particularly disruptive for them, and theyre often less willing to push through it

3C), we next examined the impact of ECM cues on the protein levels and subcellular localization of MITF (Figs

Why do two patients get different results from the same peptide