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This decline in sexual desire appears to be driven by a combination of factors, including: Disruption of neurological signaling involved in arousal Hormonal changes, especially in men receiving androgen deprivation therapy Psychological effects related to cancer diagnosis, surgery, and changes in self-image This means many men find themselves in a frustrating position after prostate cancer treatment: They are still physically capable of orgasm They may or may not achieve erections reliably But the desire, mental arousal, and sexual drive are significantly diminished This disconnect is where many traditional erectile dysfunction treatments fall short

Int J Mol Sci 2022;23:4259

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