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The overall metabolic, cardiovascular, and weight-related benefits of these medications are well-established and should be weighed carefully against manageable side effects

Yet, treatment of disease with antioxidant approaches has nearly uniformly failed (19, 20), perhaps partly because oxidative stress is often compartmentalized or driven by multiple nonspecific (chemical) and specific (enzymatic) pathways

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Benjamin DI, Brett JO, Both P, Benjamin JS, Ishak HL, Kang J, Kim S, de Morree A, Arjona M, Nutter CW, Tan JH, Dulay H, Louie SM, Nomura DK, Rando TA (2023) Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging