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In controlled laboratory and pre-clinical research settings across EU and European institutions, Tirzepatide is studied across dual incretin receptor pharmacology, GIPR biology, beta cell function, central appetite neurocircuitry, adipose tissue metabolism, cardiovascular biology, and comparative incretin pharmacology: Dual GIPR and GLP-1R Co-Agonism Pharmacology Tirzepatide is the reference dual incretin co-agonist for characterising simultaneous GIPR and GLP-1R activation from a single molecule

doi: 10.1152/japplphysiol.00002.2003

Serious Complications (Very Rare): Extremely rare but possible severe side effects can include congestive heart failure in individuals with certain heart conditions, or polycythemia vera (a blood disorder)