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Furthermore, metformin treatment alone was demonstrated to significantly induce cell death in both HCT116 and SW837 cells, although this effect was more pronounced in HCT116 cells, supporting previous studies (33, 63)

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The cross-sectional fiber area (CFA) of the GM showed that 10 mg/kg/d L-carnitine treatment resulted in a 52.0% increase in area compared to the cachexia control, while 1 mg/kg/d L-carnitine treatment resulted in a 21.7% increase (Figur 4C, E)

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