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In comparison with naturally occurring receptor ligands, retatrutide has lower potency at the human glucagon and GLP-1 receptors, at approximately 0.3- and 0.4-fold, respectively, while showing markedly greater potency at the human GIP receptor, at about 8.9-fold

For those of us who follow therapeutic innovation and mechanism-of-action breakthroughs, this is one to keep on the radar

Lastly, the results of these studies are inconsistent