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Side Effects * Dry cough * Dizziness * Hypotension * Hyperkalemia * Headache * Fatigue * Renal impairment * Angioedema (rare but potentially life-threatening) Contraindications * Pregnancy (especially the second and third trimesters) * History of ACE inhibitor-induced angioedema * Bilateral renal artery stenosis * Significant hyperkalemia * Concomitant use with certain medications in selected patients (e.g., some combinations affecting the reninangiotensin system) Monitoring * Blood pressure * Serum potassium * Serum creatinine and estimated glomerular filtration rate (eGFR) * Clinical signs of hypotension or angioedema Drug Interactions * Potassium supplements and potassium-sparing diuretics may increase the risk of hyperkalemia

Over the last two decades there has been studies that has changed in the view of the role of the luminal microbiota to also include significant impacts on host, via interactions with the GIT that may even be bidirectional

Grill JD, Tsoh JY, Nam B, et al

Risks of Any Cancer in the Tirzepatide versus Control Groups Table 3