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186 In contrast, restrictive procedures like SG have less impact on the small intestine but may still disrupt calcium metabolism through reduced gastric acid and increased PTH

However, unlike Mounjaro, orforglipron can be taken as a tablet once a day

They work by stimulating insulin release with food, suppressing glucagon (which raises blood sugar), slowing gastric emptying and signalling satiety to the brain

C-rate also is a relative metric