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Retatrutide is a triple hormone receptor agonist, which sets it apart from other GLP-1-based medications like Semaglutide (Wegovy) and Tirzepatide (Mounjaro)

The findings, published in the journal Diabetes, Obesity and Metabolism, provide real-world context to previous randomized clinical trials indicating that patients who stopped semaglutide (sold under the brand names Ozempic/Wegovy) and tirzepatide (sold under the brand names Mounjaro/Zepbound) regained more than half of the weight they lost within 12 months

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It effectively reduces weight in diabetic and nondiabetic obese individuals [96]