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is supported by grants from the National Natural Science Foundation of China (52233013), National Key R&D Program of China (2021YFA0909900), Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM609), and Steve Morgan Foundation Type 1 Diabetes Grand Challenge programme by Breakthrough T1D UK (formerly JDRF, SMF 1-SRA-2024-1064-M-N)

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