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However, in the context of chronic COPD, the function of M2 macrophages may be impaired, leading to an imbalance with M1 macrophages (112)

It was shown that 8 weeks of swimming exercise significantly upregulated Drp1, OPA1, and Mfn2 expression, restored hepatic mitochondrial fusion/fission homeostasis, and upregulated P-AMPK/AMPK, SIRT1, and PGC-1 and their target genes NRF1, NRF2, and TFAM expression

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In contrast, orally administered carnosine is subject to rapid hydrolysis by carnosinase enzymes, limiting its effectiveness for skeletal muscle loading