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Alternative and emerging therapies for severe alcohol-associated hepatitis Abbreviations AAH alcohol-associated hepatitis ALD alcohol-associated liver disease CYP-450 cytochrome P450 enzyme system DAMPs damageassociated molecular patterns ELAD extracorporeal liver assist device FMT fecal microbiota transplant G-CSF granulocyte colony stimulating factor INR international normalised ratio MDF Maddreys discriminant function MELD model for end-stage liver disease PAMPs pathogen-associated molecular patterns RCT randomized controlled trial SAH severe alcoholassociated hepatitis TNF- tumor necrosis factor alpha REFERENCES 1

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It consists of 29 amino acids the first 29 residues of the 44-amino-acid GHRH molecule with modifications to enhance metabolic stability