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Thanks to advancements in regenerative medicine, PRP therapy offers a promising alternative for patients who havent found relief through traditional treatments

As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

This underscores the importance of balancing mitophagy in IDD to prevent excessive ferroptosis and provides a theoretical foundation for developing comprehensive therapies