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The endogenous circadian clock is adjusted to the actual environmental factors such as temperature (Greenham and McClung, 2015) or light conditions, the latter is mediated by photoreceptors, especially by phytochromes (red and far-red light receptors), and cryptochromes (blue light receptors)

Leuk Res 14(9):771-7, 1990

This vitamin is a potent antioxidant that helps protect the skin from damage and supports its natural healing process

However, consistent benefits on hard outcomes have not been demonstrated across CKD settings, likely reflecting heterogeneity (baseline vitamin D status, stage, co-therapies, endpoints) and formulation/dosing differences (D vs