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(2025) Disproportionality analysis of GLP-1 receptor agonists combined with metformin based on the FAERS database.Sci Rep 15, 2.Xie Z, Hu J, Gu H, Li M and Chen J (2023) Comparison of the efficacy and safety of 10 glucagon-like peptide-1 receptor agonists as add-on to metformin in patients with type 2 diabetes: a systematic review.Front

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In this review we have also highlighted and critiqued some of the key clinical and laboratory-based studies that provide data supportive of the hypothesis that metformin, independent of its anti-hyperglycemic actions, has benefits that in principle can slow cellular aging and enhance healthspan and lifespan

Some providers recommend methenamine hippurate as a non-antibiotic prophylactic option for patients who want to avoid long-term antibiotic use